The Anastrozole research chemical has become a miracle peptide over the past 2 years. We take a closer look at what this medical miracle worker can do.
Anastrozole is a drug that is approved for the supportive drug treatment of hormone-dependent breast cancer in women after menopause. It is a substance from the active ingredient group of aromatase inhibitors .
Anastrozole is synthesized industrially in a four-stage process from α,α’-dibromomesitylene. In the first synthesis step, a nucleophilic substitution takes place , in which the α,α’-dibromomesitylene is reacted with potassium cyanide using a phase transfer catalyst to form the corresponding dinitrile. This is followed by exhaustive methylation with methyl iodide. In the last reaction step of the chemical synthesis of anastrozole with N-bromosuccinimide, the corresponding benzyl bromide derivative is produced by means of a radical bromination, which is reacted in the last step in a basic medium with 1,2,4-triazole to form anastrozole.
3 mechanism of action
The central effect of anastrozole is based on a highly effective inhibition of the enzyme aromatase . This enzyme catalyzes the conversion of androgens into the estrogen types estrone and estradiol . Due to the persistent inhibition of aromatase, there is a continuous drop in the estrogen level in the circulation with the duration of action of anastrozole. As a result, fewer and fewer hormones are available for the proliferation of the malignant mass – breast cancerand further growth of the tumorous tissue. This results in a very effective inhibition of growth of the cancerous growth and thus initially also protection of the surrounding mammary tissue from infiltration and destruction by the breast cancer. A pharmacological feature of anastrozole that should be emphasized is the fact that on the one hand it has no steroid structure and on the other hand it reversibly inhibits aromatase. This is a key difference from the active ingredient exemestane , which acts as an irreversible aromatase inhibitor.
Research Chemicals Anastrozole Effectiveness
Another special feature of the effectiveness of anastrozole is its very targeted, direct effect on the tumor , as it also inhibits aromatase within the malignant (malignant) tissue. This allows a much more precise and effective fight against breast cancer. In addition, Anastrozole is highly effective: A single dose of 1 mg of the active substance reduces the estrogen level by 70% in 7 days and up to 80% in 14 days. Anastrozole does not have an estrogenic, androgenic or gestagenic effect.
4 Use in sport as a doping substance
An increased level of female sex hormones – such as estrogens – has a certain inhibiting effect on top athletic performance. Estrogen effects lead to a greatly increased water retention and fat storage. This effect can be significantly reduced by applying an aromatase inhibitor such as anastrozole . Anastrozole inhibits aromatase, which leads to a rapid drop in estrogen levels and the effects such as water retention and fat storage are significantly reduced. However, the use of anastrozole for this purpose is strictly forbidden: The World Anti-Doping Agency (WADA) has put this active substance on the list of prohibited substances
5 side effects
increase in cholesterol