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What is Triptorelin?

  • Triptorelin is a hormone. It inhibits the production of some male and female sex hormones.
  • In women who are unable to have children (as part of IVF treatment), in a uterine fibroid, in endometriosis (pain in the abdomen due to ‘lost’ pieces of the lining of the womb lining with menstruation) and in breast cancer (along with other hormone inhibitors).
    In men with prostate cancer and hypersexuality (excessive sexual interest in men).
    In children who enter puberty too early.
  • The doctor injects triptorelin under the skin or into a muscle. You can also learn to inject yourself.
  • IVF treatment: an injection every day during a certain period of your menstrual cycle.
  • Endometriosis: an injection once every 4 weeks.
  • Breast cancer: an injection once every 4 weeks when you have finished chemotherapy.
  • Prostate cancer: an injection once a day or once every 4 weeks. Also once every 3 or 6 months.
  • Hypersexuality: 1 injection every 3 months.
  • Prostate cancer side effects: complaints may increase in the first weeks, such as problems with urination, bone pain, and muscle weakness. The complaints then subside.
  • Other side effects: impotence, breast pain, and tightness (men and women), hot flashes, sweating, abdominal pain, and headache.

Women may experience withdrawal bleeds or another vaginal bleeding. This should pass by itself. Otherwise, consult a doctor.

What is Triptorelin Used For?

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In women, the ovaries can overreact to the drug. Too many eggs can develop. Notify your doctor of severe abdominal pain, diarrhea, vomiting, or shortness of breath.

Triptorelin belongs to hypothalamus hormones. These hormones inhibit the production of male and female sex hormones.

Doctors prescribe it at reduced fertility (IVF), a fibroid, endometriosis, breast cancer, prostate cancer, premature puberty (precocious puberty), and hypersexuality.

Reduced fertility

An egg is required for pregnancy, which is fertilized by a male sperm. An egg that can be fertilized has developed a few days before, the egg is called “matured”. When the egg is sufficiently developed, it is released for fertilization. This is called ovulation or ovulation.

In IVF (In Vitro Fertilization) treatment, fertilization takes place outside the body.
For this, ripe eggs must be removed from the ovaries and then fertilized.

The doctor tries to regulate the hormones in your body precisely to ensure that the eggs mature. For this, the own hormones must first be blocked. Egg maturation is then stimulated with other medicines. When the eggs are sufficiently ripe, they are aspirated from the ovaries with a hollow needle.

Triptorelin is a drug used to block the body’s own hormone production.

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This drug is used in uterine fibroids (myomas). A fibroid is a benign growth. It can be several millimeters in size, but can also be much larger.

The uterus consists of a thick layer of muscle. In a fibroid, proliferation of the muscle tissue of the uterus occurs.

Most women have no complaints of the fibroid. Large growths can be seen as a hard curve of the lower abdomen. Some women have more blood loss and pain during menstruation. When women enter menopause, the symptoms usually disappear.

With relatively small fibroids, the contraceptive pill can reduce abdominal pain from fibroids. Progestin hormones, such as in tablets, in the injection tablet or in the hormone IUD, are also effective. These hormones reduce the size of the fibroid.
If you have many complaints of the fibroid, the doctor can operate. Sometimes by removing the entire uterus, sometimes by just removing the fibroid. In that case, your doctor will often prescribe triptorelin injections several months before surgery. It makes the fibroid smaller so that it is easier to remove. In addition, there is less blood loss during the operation.

Doctors sometimes also prescribe triptorelin for a fibroid if you are just before menopause. You should not use this medicine for longer than 6 months, because otherwise, it gives too much chance of side effects.

An injection works for about 4 weeks. If you use this drug, menstrual periods usually stay away. If the uterus was not removed during surgery, menstruation will return 7 to 12 weeks after surgery.


The uterus is lined with a mucous membrane on the inside. This mucous membrane is called the endometrium. In endometriosis, the mucous membrane is also present outside the uterus, for example, in the abdominal cavity, around the intestines, the ovaries, bladder or on the peritoneum.

The mucous membrane outside the uterus also participates in the menstrual cycle. This causes small bleeding in the abdominal cavity that can cause pain. Scars and adhesions can also develop, which can cause abdominal pain during menstruation, but also before or after this. Sometimes endometriosis is a cause of unwanted childlessness. Infertile age, 1 in 20 women has endometriosis. For women who are unwittingly childless, this is 1 in 4.

Sometimes it is helpful to use a pain reliever, such as acetaminophen or an NSAID type pain reliever, such as ibuprofen. The birth control pill can also reduce abdominal pain from endometriosis. Optionally, you can continue to use the pill for a week to stop menstruation. Progestin hormones, such as in tablets, in the injection tablet or in the hormone IUD, are also effective.

If painkillers, the pill, or progestin hormones do not help enough, your doctor may prescribe triptorelin. You should not use it for more than half a year because otherwise, it gives too much chance of side effects.
If the symptoms come back afterward or if you are in a lot of pain, the gynecologist can do keyhole surgery and remove the mucous patches. Unfortunately, endometriosis sometimes returns. By using triptorelin after surgery for 6 months you have less chance of the disease coming back.

Triptorelin inhibits the production of the sex hormones estrogen and progestin. This reduces the amount of uterine lining on the endometriosis sites. This reduces the pain.
Usually, the menstrual period remains after the first month of treatment. Menstruation returns 7 to 12 weeks after the last injection.

Cancer is a collective name for more than a hundred different disorders, in which body cells multiply unrestrained. The result is tumors (growths) or abnormalities in the blood and lymphatic system. It is a serious illness that, if left unchecked, can be fatal.

Thanks to new research, good treatment for many types of cancer is now possible. With rapid treatment, you prevent cancerous growth from growing in the surrounding tissue or from spreading. Metastases develop cancer in other places in the body.

Each cell contains DNA. DNA contains the hereditary properties of our body, such as the blood group and the color of the eyes. Because of the DNA, cells know what to do, for example also how quickly they have to divide. In a cell division, two daughter cells arise from one cell, with exactly the same DNA as the mother cell. If the piece of DNA that controls cell division is damaged, the cell can divide faster. The daughter cells of each cell contain the same damage in the DNA. As a result, these cells also divide unrestrained, resulting in cancer.

It is often unknown how the damage in the DNA occurs. It sometimes seems to be due to chemicals such as tar in tobacco smoke, or asbestos, alcohol, too much or too fatty food, radiation, or a hereditary predisposition.

Cancer is an insidious disease. Each cancer type causes different complaints. In the early stages, there are often no symptoms at all. Pain can only be felt if cancer against nerves presses.

Some complaints occur in almost all cancers, such as severe fatigue, loss of appetite, and strong weight loss (for example, more than three kilos per month).

Triptorelin is used in breast and prostate cancer.

Breast cancer
With DNA damage, cells in the breast can grow uninhibited. You may feel the tumor as a small lump. Sometimes the tumor is spread in the breast and you cannot feel it. Sometimes you may notice that the skin on the breast is dented, or it is red and swollen. The nipple can also pull in or moisture can come out of the nipple.
The female hormone estrogen can promote the growth of cancer cells. Estrogen hormone is produced by the ovaries.

Breast cancer is usually treated with surgery, radiation, medicines for female sex hormones and chemotherapy. Usually, this involves a combination of treatments to increase the chance of a cure.

When you have finished the treatment, there is a chance that the breast cancer will come back. Or that there are still small metastases. Therefore, treatment is continued after chemotherapy. This is called adjuvant therapy.

One of the drugs used in adjuvant therapy for breast cancer is triptorelin.

Triptorelin reduces the production of the female sex hormones estrogen and progestin. This inhibits the growth of remaining breast cancer cells.

Prostate cancer
The prostate is a gland in the lower abdomen. It’s around the urethra. This gland makes the prostate fluid. This is the moisture that comes out together with the sperm during ejaculation.

With DNA damage, the cells in the prostate gland can grow uninhibited. In this place the prostate hardens. The tumor can make the prostate bigger. The tumor can squeeze the urethra, making urination more difficult. The male hormone testosterone can promote the growth of cancer cells. Testosterone is produced by the testes.

Prostate cancer occurs in men over the age of 50.

Prostate cancer is usually treated with surgery, radiation and testosterone medications, such as triptorelin. Sometimes courses of chemotherapy are needed.

Testosterone drugs alone are usually not enough to cure. However, the disease and complaints are curbed. One of the testosterone medications that your doctor may prescribe is triptorelin.

It is also sometimes given after a course of radiation to reduce the chance of the disease returning.

Triptorelin reduces the production of testosterone. This inhibits the growth of prostate cancer cells.

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