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What is LGD 3033?
LGD-3033 is a Selective Androgen Receptor Modulator (SARM). One of the strongest out there.
LGD 3033 is currently in a preclinical phase; that is, there are no studies in humans. But there are studies in animals to investigate how to treat diseases such as hypogonadism, and osteoporosis, which significantly improve the growth potential of lean muscle mass and help older people maintain strength and skeletal tissue.
It is a modification of the LGD structure, which gives us completely different characteristics than the usual LGD-4033.
There is little scientific literature or people’s experiences, so it will not be possible to speak as objectively as with other SARMs.
How Does LGD-3033 Work?
LGD 3033 works similar to other SARMs, because it selectively affects androgen receptors, playing a crucial role in the role of muscle gain. It has a non-steroidal structure orally administered, then binds to androgen receptors in a highly selective manner and with high affinity compared to other SARMs.
This selectivity mainly affects the receptors in the muscles and bones.
Is LGD-3033 Anabolic?
As for how androgenic LGD-3303 is, it is a full agonist in muscle and a partial agonist in the prostate less than its companion LGD-4033.
Here you can compare, dosages, how much muscle can be gained (anabolism) and how much it affects the prostate of rats (endogeneity). So it can be stated from how androgenic this substance is.
At a minimum dose of 1mg/kg per day (which would be a recommended dose for a person with degenerative diseases and not a cycle), the effect on the prostate was minimal compared to rats that were not using anything.
Thanks to this, we can say that it is a very selective and slightly androgenic substance. Although this does not mean that it does not affect more androgenic SARMs, as we will see later.
LGD 3303 Results – Muscle Mass Gain
In a study conducted on castrated rats, doses of lgd3033 from 0.8mg/kg to 3mg/kg were administered, where lost muscle mass was restored at a dose-dependent rate, maintaining prostate size.
It is a viable alternative for gaining and maintaining muscle mass without too many effects on other androgen receptors.
What to Expect from LGD 3033 Dosage?
LGD-3033 is one of the most powerful of all known SARMs, increasing muscle and strength.
Anecdotal evidence says that it gives a complete look, but in a dry way, without any subcutaneous fluid retention. The fullness is through nitrogen retention. It is uncommon as dry compounds don’t usually make the muscle look complete; this is typical of more watery compounds, although this is not the case.
LGD 3033 is the perfect compound for instantly gaining size for an event, photo shoot, important workout, etc. Regarding the actual size, we could gain from a cycle; this compound will also give us some very respectable gains comparable to a cycle with high doses of lgd-4033.
Strength gains are also very noticeable from the first week, comparable to the well-known RAD-140.
Therefore, with a cycle of this substance, one can expect a significant increase in lean muscle mass and a considerable increase in strength.
Users of this compound report quite evident aggression when using this substance. It is usually used as a pre-workout to get that energy shot and burst the irons.
If it is used alone before training, this effect is quite favorable; if you cycle it, the results would be similar to RAD-140.
All SARMs lower HDL, LDL and triglycerides. LGD 3033 is very dose-dependent, and we always recommend having your blood tested before using any compound.
Cardarine (GW-501516) or SR9009 can alleviate this effect.
No studies support this, and LGD 3033 is not methylated like oral steroids. SARMs put extra work on the liver. Ideally, this compound can cause some liver toxicity, although less than many anabolic steroids.
LGD-3033 is a reasonably safe substance in this regard, if it were not for its suppression, it could be used for several weeks as a continuous pre-workout.
To be sure, always do a blood test.
Experts always recommend something to help the liver, like NAC or TUDCA, when it comes to cycling.
SUPPRESSION OF ENDOGENOUS TESTOSTERONE
It is the most critical side effect for someone not using a testosterone base. LGD-3303 is very suppressive, leading to slow testosterone during the cycle.
Although suppression is highly individual, this substance is even more suppressive than Rad-140, and take care when using it.
Some patients notice an increase in libido even in the last weeks of the cycle. It is because LGD-3033 is replacing the function of testosterone in the body.
With a cycle, PCT is necessary to recover from this substance, and we do not recommend it for people with low testosterone.
LGD-3303 Ligandrol SARM Studies
In preclinical studies, researchers used 1mg/kg per day, enough to restore anabolic support to castrated rats.
The doses used anecdotally have been between 10mg and 20mg in humans; it is probably closer to 20mg daily.
NOTE: Even at a low dose of 10mg/day, relatively high suppression can occur and PCT after.
Patients who have used it at a dose of 20mg say they have seen better results than with half the dose, so its optimal point is probably at that dose.
It does not matter if the person is fasting or not at the time of taking it.
The exact bioavailability of LGD-3033 is unknown but is theorized to be relatively high. It is probably most effective in an injectable way, as is the case with all SARMs.
Can Women Use SARMs?
LGD-3033 is a potent and relatively selective SARM. However, it is not recommended for women. Some SARMs give women dream gains with practically zero risk of virilization, such as S4 or LGD-4033.
Does LGD3033 Affect Testosterone Levels?
As we have said before, this is a very suppressive SARM, and in a few weeks, it will leave us with low testosterone levels.
Remember that when it reaches zero, neither estrogen nor DHT is created and achieves no muscle gain.
It leaves us at the mercy of our hormones and in a compromised position when we finish the cycle. As well as an inability to feel free to experiment with dosage. As well as the side effects of low testosterone.
That is why we recommend using testosterone with this substance, although it is possible to cycle without it and achieve good gains.
Is LGD-3033 Legal?
Since 2008, the use of SARMs has been prohibited by the US Anti-Doping Agency (USADA), also registered with the World Anti-Doping Agency (WADA).
LGD-3033 is not permitted in competitive sports as a professional athlete.
The exact detection time is not precise, but it is estimated to be 2 to 4 weeks since it has a shorter lifespan.
Usually, when its half-life has passed five times, the amount of substance in your body is negligible.
Therefore, if you are an athlete undergoing anti-doping tests, you should be careful and reconsider using this substance.
No studies show that one is more potent than the other. According to anecdotal evidence, it has higher potency in building muscle mass and gaining strength than LGD-3033. In addition, the doses at the diminishing returns are higher, and the suppression also, so it is probably potent LGD-3033.
Unlike LGD-4033, LGD-3303 is a dry compound, making it a more viable definition substance. It does not tend to retain water or hide the muscle definition; that is the goal of this phase.
LGD-3033 is also a compound that will maintain all the muscle, giving us a more defined appearance than we really have.
In a volume phase, LDG-4033 is also a viable option and better because the extra water weight gives us more strength and lubricates the joints. But it will depend on the objectives of each one.
It is up to each one to choose if they prefer to gain a little more mass and more excellent suppression or if they want a more watery or dry look during their cycle.
LGD-3033 works in every phase, in volume, to build mass.
It is very versatile and used in a volume definition and recomposition phase.
LGD 3033 Side Effects
There are limited records on potential side effects. So if you know of any more then mentioned in this post, it would be helpful to put them in the comments.