Total nutrition SARMs or Selective Androgen Receptor Modulators exist for research purposes only and are not for human consumption. From a classic point of view, SARMs, as the full name suggests, are substances that are selective. This means they explicitly, dock onto the androgen receptors in the body and develop their effect. Androgens are a class of hormones that belong to steroids. The most prominent example of an androgen is testosterone, which is the male sex hormone in the body. “Androgen” means that these substances have a masculine effect, which manifests itself in the primary and secondary masculine gender characteristics (beard growth, deeper voice). Nevertheless, women also have a certain level of androgens, which mainly controls their sex drive.
Is SARMs Nutrition Effective?
Androgenic hormones have masculine effects and also anabolic effects. This means that they mainly bring about an increase in muscles. Different androgens have a different ratio between anabolic and androgenic effects. Dihydrotestosterone (DHT), which is produced from testosterone, is much more androgenic than normal testosterone, but less anabolic. This androgenic effect in particular is responsible for some of the negative side effects of testosterone, such as hair loss on the head (alopecia), growth of the prostate, or increased body hair growth.
SARMs vs.Steroids?
The SARMs nutrition is selective and specifically influences the steroid receptors, without being steroid hormones themselves, which can avoid some side effects. They neither have the structural requirements to be converted into estrogen nor does the body perceive them as hormones. Nevertheless, through the specific change – in this case, activation – or inhibition of the androgen receptors, they develop a similar effect to steroids.
Due to their selectivity, however, SARMs can also have a very specific effect on the respective receptors only in certain tissues. Since they were developed explicitly for medical use, attempts have been made, for example, to bypass the effect on the receptors in the prostate in order to minimize the enlargement of this organ, as can be the case with classic steroids.
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Generally, other substances that do not work on the androgen receptors are also counted among the SARMs. However, they have a very similar effect on other hormonal systems and are therefore often classified in this group. Examples are
- MK-677 which is supposed to increase the body’s own growth hormone release
- GW-501516 or Cardarine is supposed to regulate the transcription factor PPAR-gamma upwards
- YK-11 is also classed among the SARMs group but according to other sources it inhibits the activity of the myostatin gene
Does Medicine Need to Replace Steroids with SARMs?
In medicine, steroids are mainly used for reducing testosterone production or diseases that are associated with muscle wasting. Another use is for burn victims or Crohn’s disease patients to improve their regeneration and quality of life. As discussed earlier, the exogenous intake of these hormones is not free from potential side effects. A female burnt victim, who is receiving testosterone therapy to accelerate wound healing, could experience male sexual characteristics, beard growth, widening of the jaw, enlargement of the clitoris, and a deeper voice.
Is SARMs Legit?
Total SARMs Nutrition is used illegally in weight training and bodybuilding for the same reasons as they are used in medical research. The focus here is on building muscle, maximizing fat loss without losing significant amounts of lean mass. They have the potential for fast recovery from injuries through increased bone metabolism and muscle mass. However, some athletes also use SARMs to lose less muscle mass between steroid or prohormone regimens without getting in the way of the hormonal axis recovery. But we would like to point out that this is information only and they are not permitted for this use.
Potential Benefits of SARMs Total Nutrition
Another potential advantage of SARMs nutrition over steroids is that they are available orally and do not need to be injected regularly into the muscles or subcutaneous fat. Although there are also orally available steroid derivatives in the world of doping abuse, in the majority of cases these have a special compound that makes them resistant to breakdown in the liver. More precisely, one speaks of 17-alpha-alkylated steroids, in which an alkyl group is attached to the alpha position of the 17th carbon atom. However, it is also this chemical modification that makes the substance toxic to the organ, which is why such substances are nowadays hardly of any clinical relevance. In contrast, SARMs do not require such a change and are therefore not toxic to the liver, at least not via this mechanism.
The Side Effects SARMs Nutrition
Even if steroids and prohormones can lead to rapid and strong increases in muscle mass and strength, depending on the dosage, they put a considerable strain on the body. In most cases, it leads to a number of side effects. Among other things, the risk of prostate cancer, hair loss on the head, acne, increased body hair growth, gynecomastia, high blood pressure (hypertension), poor liver and cholesterol levels in the blood, heart muscle growth, and suppression of the body’s own increases
A further side effect of exogenous steroid intake is the suppression of the body’s own hormone production. If you add testosterone to the body from the outside and thereby artificially raise the level in the blood, the body’s own production is stopped. However, only testosterone, which is produced by the body itself, can influence the production and maturation of the sperm. The reason for this is that this also requires a hormone from the pituitary gland, which signals the testes to produce testosterone, but also the hormones LH (luteinizing hormone) and FSH (follicle-stimulating hormone). The intake of steroids from the outside can lead to infertility.
Other side effects of androgens, such as enlargement of the mammary glands (gynecomastia) or water retention under the skin, are caused by the conversion to estrogens by the enzyme aromatase. One also speaks of a so-called “aromatization”.
Total Nutrition SARMs Review
Several types of SARMs also activate an enzyme called AMP-activated protein kinase (AMPK), which causes the body to provide energy from stored reserves. This means that they can play a major role in the process of fat release and fat burning. Man-made testosterone can lead to an increase in muscle mass and a decrease in fat mass, but not without suppressing the concentrations of LH and FSH. SARMs, on the other hand, should generally not lead to such suppression as long as one does not use particularly high doses. This point should suggest that SARMs are a safe alternative to conventional steroid therapies in the long term. Still, high doses are what we can see from their use in the fitness scene.
Androgens are still involved in bone metabolism. They support the building of the compact outer layer of the bones, which has positive effects on many health parameters. In addition, androgens reduce the breakdown of bone substance, which is one of the reasons why many people suffer from osteoporosis in old age when the body’s own production of androgens, but also estrogens, decreases.
