SARMs seem to be the preferred choice for bodybuilders and other athletes these days and if you know where to buy SARMs bodybuilding products such as LGD-4033 and others you can safely ignore this article.
So let’s get started by telling you what SARMs are for those that are new to this and you will soon get a grasp of what
SARMs do and how you can achieve fantastic results very fast.
What are SARMs Used For?
SARMs are substances that were born with the clinical objective of recovering muscle mass (since this is a predictor of life expectancy and strength) in burned, polytraumatized patients, after major surgeries, etc. and being a better option than Anabolic Steroids Androgenic in terms of both long and short term health and in terms of efficiency.
This purpose is still under investigation but what has happened with SARMs is that they have gained a lot of popularity in the fitness and other sports sector as they have many advantages over Aas.
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DIFFERENCES WITH STEROIDS
The first difference is the origin, unlike Anabolic Androgenic Steroids whose mother hormone is Testosterone which is produced by the body itself and the rest of the compounds are artificially synthesized from it, SARMs are purely synthetic substances of origin, and structurally they do not have nothing to see.
The structure of SARMs partly mimics a group of compounds called Antiandrogens such as Flutamide, Hydroxyflutamide and Bicalutamide, which already interact on androgen receptors.
These receptors are structures of a protein nature that are present in all the cells of the body and their activation, let’s say they have certain beneficial or negative effects depending on the tissue, in the case of muscle and bone it is positive but in heart and kidney tissue it is negative.
If we made a comparison of what SARMs and Aas are, taking into account the selectivity of SARMs, these are like a sniper (it only affects the cellular targets of muscle tissue) being much safer and less harmful at medium and low doses On the other hand, Anabolic Steroids are shrapnel, that is, they affect all organs and tissues.
SARMs do not need esterification (Propionate, enanthate, cypionate …) to be administered injectable, nor do they need a methyl group (17-alkylation) to be available orally so they are the only chemicals for physical enhancement that act on orally bioavailableAR .
Since SARMs appeared in the world of Fitness they have been received with great suspicion and mistrust but the users themselves have realized how powerful these compounds are even using them at low doses. There are already many well-known characters who make preparations to compete only with SARMs , as well as fitness influencers .
The relative potency of SARMs is much higher than that of Aas, between 2 times in the case of S-4 up to 8-10 times in the case of S23, we speak of milligram by milligram, then we refer to the relative potency or Anabolic Units (AU).
On the other hand, compounds such as Oxandrolone are 2 times more powerful, Oxymetolone is 0.7 and Trenbolone are 3.5 times the power over 1 that is Testosterone, it should be noted that all these figures are in relation to mass gain lean muscle and do not take into account the appearance that certain substances can give or what can support fat loss, in this sense Anabolic Steroids are superior.
SIDE EFFECTS OF SARMs
Unlike Anabolic Steroids, SARMs have selectivity, which refers to what we have said before about sniper and
At low medium doses the adverse effects of SARMs will be mild liver stress which is not toxicity as occurs with Oral Steroids. Worsening of the lipid profile and a decrease in testosterone secretion.
SUPPRESSION OF THE HYPOTHALAMIC PITUITARY GONADAL AXIS
Interactions on the estrogen and progesterone receptor would also inhibit the axis and are in fact the most powerful inhibition pathways.
A single injection of Testosterone generates a complete inhibition, but it is due to the aromatization of Testosterone in Estradiol and this causes a great inhibition, compounds such as Trenbolone that exert an interaction with the Progesterone receptor and Estrogens, cause a triple inhibition .
On the other hand, the SARMs only act on the ARs of the hypothalamus, the inhibition is present but it is much less, it takes a lot of dose and time to reach the complete inhibition, we will handle what is called “Inhibition constant” to refer to the capacity that each compound has on average in normorresponders subjects.
In the case of SARMs it is really unlikely that this will occur, but with the use of other drugs that cause hepatotoxicity, the use of SARMs could aggravate this and it could be that canicular cholestasis develops.
This in the long term could be atherogenic, that is, contribute to the formation of atheroma plaque and is a potential risk of cardiovascular diseases, but this can be solved with certain protocols and the use of some supplements such as Health Support, which It has Red Rice Yeast, which acts as a statin, reducing levels of total Cholesterol, LDLc and raising HDL.
Another of the drugs proposed to solve this problem is Cardarine, which has the ability to raise HDLc as well as lower LDL to avoid dyslipidemia.
However, at very high doses they seem to raise the hematocrit due to the interaction with red blood cells, they can cause hair loss and it is speculated that the adverse effects may be practically the same as Aas, but being so powerful, it does not take much doses so that they are really a great option to add anabolism to a pharmacological therapy, taking weight off conventional steroids of which we already know the adverse effects that they will bring to the health of athletes in the medium and long term.
One of the problems found in the legitimacy of the products, with the rise of SARMs in the Fitness community, many have seen a way to give way to cheap oral steroids to manufacture such as Dianabol or Winstrol, and they end up having effects Atypical unwanted adverse events from the use of SARMs.
Luckily at Peptides Warehouse we have a quality product, tested and certified, so that customers have all the guarantees that they are receiving what they buy as well as being able to help them in taking care of their health while obtaining all the benefits that these compounds bring them.